2016, vol XXIV, # 2
2016, vol XXIV, #2, page 5
M. V. KRASNOSELSKYI, L. O. HAISENIUK, G. V. KULINICH, L. YA. VASYLIEV
SI Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine, Kharkiv
PRACTICAL ORGANIZATIONAL AND SCIENTIFIC ACTIVITY IN SI GRIGORIEV INSTITUTE FOR MEDICAL RADIOLOGY OF NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE CONCERNING THE ISSUES OF CHORNOBYL POWER PLANT ACCIDENT CONSEQUENCES
Summary. The basic directions of activity and achievement with practical-organizational and scientific activity of State institution «Grigoriev Institute for medical radiology National Academy of medical Science of Ukraine» in overcoming of medical consequences of Chernobyl Nuclear Power Plant accident are traversed.
Keywords: Chernobyl Nuclear Power Plant accident, medical consequences, organization of medical help, medical condition.
2016, vol XXIV, #2, page 11
ЮЛІАН ТОДОСІЙОВИЧ КІНОШЕНКО
ПРАВДА ГІРЧИТЬ І ДОНИНІ
Колишній директор ДУ «Інститут медичної радіології ім. С. П. Григор’єва НАМИ України» професор Ю. Т. Кіношенко у своїй біографічній повісті «Дорогами моей жизни» розповідає, як колектив інституту переборював труднощі в ті перші «чорнобильські» дні.
Наведено уривок із цих спогадів.
2016, vol XXIV, #2, page 14
N. O. ARTAMONOVA1, YU. V. PAVLICHENKO1, A. G. SHEPELEV2
1SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
2National Science Center Kharkov Institute of Physics and Technology
30 YEARS OF CHERNOBYL DISASTER: SCIENTOMETRIC ANALYSIS OF SCIENTIFIC PUBLICATIONS
The purpose of robots. To evaluate the accumulated knowledge on the health consequences of Chernobyl accident by scientometric analysis of scientific publications.
Materials and methods. Used scientometric approach to the treatment of scientific communication tools. Results. Aassessed amount of accumulated knowledge about the health effects of Chernobyl accident by scientometric analysis of scientific publications in 30 years. Information base of research included Medline on PubMed, a database IAEA «INIS» and platform Science Direct. It is shown that the absolute leader in the production of relevant information is INIS as a specialized resource for nuclear power. Medline covers most Shirshov range of content on the health effects of the Chernobyl accident. Identified leaders of the country, leading magazines and thematic distribution of publications.
Conclusions. Holding scientometric analysis has allowed the country have seen leaders who are engaged in these issues, and a group of leading scientific journals, which are placed on the pages of questions about the health effects of the Chernobyl accident. It was also found that the intensity of study questions regarding the impact of the Chernobyl accident on human health since 1999 has decreased significantly. bywords: Chernobyl accident, scientometric analysis, INIS.
2016, vol XXIV, #2, page 19
V. A. PRYLYPKO1, A. A. PETRICHENKO1, YU. YU. OZEROVА 1, А.У. КОTSUBINCKIY2
1State Institution «National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine», Kyiv
2State Institution «Specialized Healthcare № 3 of the Ministry of Health of Ukraine», Varash, Rivnens’ka oblast SOCIAL AND MEDICAL-ORGANIZATIONAL ISSUES PROTECTING OF POPULATION ZONE OF OBSERVATION NPP
Objective. To study the state of social well-being and public opinion on medical provision population the zone of observation and readiness medical institutions to provide specialized medical care in case of emergency at the NPP.
Materials and Methods. Studied the the social conditions of the population the zone of observation Rivne NNP using sociological research methods, the test integral index of social well-being. In a survey of the working population was used not repeated probabilistic selection. The sample of respondents was 220 people sampling error of 6.7 %. To study the readiness medical institutions to provide specialized medical care in case of emergency at the NPP was the method of expert evaluation. Were formed five expert groups (78 persons) responsible for radiation protection status of different populations surveillance zone RNPP. In matters developed questionnaires used are different rating scale: nominal, ordinal and interval. When they processing used statistical and mathematical methods, which are designed to analyze no numerical information.
Results. The overall indicator of social well-being of the population in the observation zone of 53.40 points out of 100 possible. The results of testing of urban and rural of the population difference between them was not found. The revealed reliable direct correlation between the level of social well-being and subjective assessment of the environmental situation in the residence (r = 0,194; p < 0,01) and wellbeing (r = 0,353; p < 0,01). Negative impact on social well-being of the socio-political sphere, the sphere of social security and social relations. According to data public opinion the biggest complaints from the population causing providing necessary medicines, the cost of medicines, provision of quality diagnostic equipment hospitals, doctors competence. Experts indirectly (3 points, at a scale of 1 to 5) evaluate the presence of the balance of medical institutions of technology, health and property of preventive medicines required for use in emergencies. In satellite town NPP highest level of security means protecting the population belongs to the stable iodine drugs and respirators (4.54 and 3.54 points respectively, at a scale of 1 to 5). Lower provision kits and personal protection. In rural areas, according to experts, provision of stable iodine drugs, personal protective equipment, first aid kits is 2 points 5. Provision of respirators is 1.5 points. Conclusions. The protective measures in case of emergency in observation zone RNPP implemented under the work plan for daily operation in the area of supervision and mode of emergency. Changing sources of funding in recent years and its decline led to a reduction of funding of articles relating to medical facilities readily surveillance zone to provide specialized medical assistance in case of emergency.
Keywords: zone of observation NPP, social health, the medical provision, security emergencies.
2016, vol XXIV, #2, page 27
V A. LEVCHENKO, I. P VAKALUK, M. M. KARABANOVYCH, I. I. SVYSTUN, A. I. OVCHAR, M. Z. KRUL
Ivano-Frankivsk National Medical University
ANALYSIS OF THE RADIATION SITUATION IN THE AREA OF ANTHROPOGENIC IMPACT BURSHTYN TPP
Summary. The main objective of the study is to evaluate the radiation situation of natural and technogenic zone around Burshtyn TPP. The study analysis of soil samples showed that the main areas around fonoutvoryuyuchymy radioisotopes Burshtynskoy TPP is radionuclides of families 238U, 232Th and 40K.
Keywords: thermal power plant, ash, background radiation, radionuclides.
2016, vol XXIV, #2, page 30
T. F. ZAKHARCHENKO, S. V GULEVATYI, I. P. VOLYNETS
SI «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. Ukraine», Kyiv
THE CUMULATIVE EFFECT OF RADIOIODINE ON FUNCTIONAL ACTIVITY OF NK-CELLS AND NEUTROPHILS IN PATIENTS WITH DISTANT METASTASES DIFFERENTIATED THYROID CANCER
Summary. Defines the function of the innate immune parameters in patients with differentiated thyroid cancer (DTC) with distant metastases to lungs (LM) of the young and older, who obtained to 5 courses of radioiodine therapy (RIT), and that obtained 5 or more courses of RIT. It was revealed that the cytotoxic activity of NK-cells and metabolic activity of neutrophils (NF) the blood of patients depends on the cumulative activities of radioiodine. With increasing number of courses RIT NK-cell activity and the NF is reduced. Metabolic activity of NF is reduced to a greater extent in elderly patients.
Keywords: distant metastases of thyroid cancer, radioiodine therapy, the activity of NK-cells, the metabolic activity of neutrophils, age.
2016, vol XXIV, #2, page 34
I. Yu. CHERNIAVSKYI, V. V. MARUSHENKO
National Technical University «KhPI», Guards department of military training of the behalf of the Verhovna Rada of Ukraine, Khar^v
MILITARY-RADIOLOGICAL ASPECTS OF THE SPATIAL DISTRIBUTION OF THE ABSORBED DOSE OF PULSED GAMMA-NEUTRON RADIATION
Summory. In order to optimize radiological principles of military radiation safety systems this paper examines possible ways of accounting the spatial distribution of the absorbed dose by assessment of the uneven irradiation rate.
A comparative evaluation of the doses ratio of neutron and gamma radiation was conducted, and obtained dependence of unevenness factor and the reduction index of biological effect which depended on distance from the center of the explosion of different types of ammunition. In general, irradiation of the human body in a field of pulsed gamma-neutron radiation of neutron ammunition is much more uniform than in the cases of irradiation in the explosion of thermonuclear ammunition. Functional of distribution of dose load depends on the ratio y/n components, which is dependns on the distance from the center of a nuclear explosion, on the presence of the scattered radiation; onthe spectral features of the type of ammunition (the presence of capture gamma radiation in the air and soil); on human orientation in a field of gamma-neutron radiation; on the human body screening Keywords: gamma-neutron flux of penetrating radiation, unevenness of irradiation.
2016, vol XXIV, #2, page 41
N. M. STEPURA, G. A. ZAMOTAYEVA
SI «V. P. Komisarenko Institute of Endocrinology and Metabolism, Natl. Acad. Med. Sci. of Ukraine», Kyiv
CONTENT OF CIRCULATING IMMUNE COMPLEXES IN PATIENTS WITH THYROID CANCER OF ALL AGES WITH METASTASES TO LUNGS IN THE COURSE OF RADIOIODINE THERAPY
Summary. The present article is dealing with the data of a comparative analysis of the content of circulating immune complexes in blood serum of patients of different age with thyroid cancer, depending on the presence of distant metastases. 267 patients have been followed, who were divided into groups depending on the presence of metastases to lungs and age: from 7 to 18 years; from 19 to 40 and from 41 to 75 years. Control groups consisted of donors of corresponding age and gender. With the aim of destruction of residual thyroid tissue and metastasis treatment, therapeutic radioiodine activities from 2000 to 6000 MBq were used. Testing of circulating immune complexes was performed on the eve of radioiodine administration and in six days, one and six months after radioiodine therapy. It has been shown that in patients with thyroid cancer, regardless of age and presence of distant metastases, radioiodine therapy leads to a reliable increase in the amount of immune complexes, with a maximum level of their production one month after radioiodine administration. In the context of radioiodine therapy, peculiarities of antigen-antibody complex formation in patients of all ages were revealed.
Keywords: differentiated thyroid cancer, iodine-131, radioiodine therapy, circulating immune complexes, age, distant metastases.
2016, vol XXIV, #2, page 45
D. MECHEV1, V. IVCHUK1, M. SOKOLOVSKA1, N. YEFREMOVA2, T GOVORUKHA2
1National Medical Academy of Postgraduate Education named after P L. Shupyk, Kyiv
2Kyiv City Clinical Cancer Center
RADIATION THERAPY IN TREATMENT OF CHILDREN BRAIN TUMORS
The aim. To evaluate the benefits of conformal irradiation to increase complex treatment efficiency of malignant brain tumors in children.
Methods. In Kyiv City Clinical Cancer Center at children’s department have been treated 43 children. All patients were from 3 to 17 years old. 40 of these patients were performed postoperative radiotherapy and 3 — radiation therapy.
Results. In supratentorial tumors were performed subtotal irradiation: 1.6-1.8 Gy per fraction to the 52-57.0 Gy for course. In medulloblastoma, ependymoma, germinoma cases patients were irradiated with craniospinal method: to the primary tumor 50-54.0 Gy, to the spinal cord — 26-30.0 Gy. According to the protocols, radiation treatment was combined with following chemotherapy.
Conclusions. Conformal irradiation at complex treatment of brain tumors in children makes possibility to ensure optimal spatial dose distribution of tumor irradiation and to conduct effective doses. Correct pre-radiation planning reduced the estimated risk of changes in the critical organs. It is very important for increasing the life quality in growing patients. Conformal radiotherapy — is highly accurate and highly effective method in the treatment of malignant brain tumors in children.
Keywords: brain tumors, children, radiation therapy, chemotherapy, operation.
2016, vol XXIV, #2, page 49
N. SPIZHENKO, T CHEBOTAREVA, A. SHKIRYAK, O. YARMAK Medical Center «Cyber Clinic of Spizhenko», Kyiv OLIGOMETASTASES AND LOCAL IRRADIATION
Summary. The concept of an oligometastatic state was first proposed by S.Hellman et al. as an intermediate state (<5 metastases) between limited primary and polymetastatic cancers in which local therapy including radiosurgery could achieve longterm survival or cure. We observed positive remission within 2-5 years at 28 patients with oligometastases after radiosurgery on the CyberKnife.
Keywords: oligometastases, radiosurgery, CyberKnife.
2016, vol XXIV, #2, page 53
V. S. IVANKOVA, T V SKOMOROKHOVA, O. Y. STOLYAROVA, N. P. DOCENKO, A. A. MAKARENKO, G. V. GALYAS
National Cancer Institute, Kуiv
IMPLEMENTATION OF MODERN TECHNOLOGY IN PRACTICE RADIOTHERAPY IN CANCER PATIENTS
Summary. The article describes the basic steps improve radiation therapy (RT) in cancer patients. The choice of a rational plan for radiation therapy and accuracy of its display during each exposure by 25 % to the success of radiotherapy. In order to solve the main task RT — summing up the dose to the tumor tumorotsidnoy at the lowest possible pressure on the surrounding healthy tissue — requires an individualized approach to the implementation of all parts of the technological chain: choice of external beam radiotherapy, conducting qualitative before radiotherapy topometricheskoy patient preparation, plan, calculation of exposure, summing up to a maximum dose to the biological target. In today’s radiology clinic for quality before radiotherapy training necessary to use a simulator, CT scanner, the computer system of 2D or 3D volumetric planning target irradiation, that is — the source of the tumor.
Keywords: before radiotherapy topometricheskaya training, target irradiation, tumor center, external beam radiation therapy, tumorotsidnaya dose.
2016, vol XXIV, #2, page 59
V. S. IVANKOVA, T. N. NESTERENKO, L. M. BARANOVSKA, T. V. KHRULENKO
National Cancer Institute, Kyiv
PREVENTION RADIATION REACTIONS AS WELL AS PREVENTION OF LATE COMPLICATIONS OF CHEMORADIOTHERAPY FOR CERVICAL CANCER
Summary. Reduction of early radiation reactions as well as prevention of late complications are done by using of modern topometric training technologies, personal computer planning and correct implementation of the planned combining radiotherapy course. Dynamic monitoring, medicamental prevention and timely correction of treatment programs helps to ensure that the conduct of chemoradiotherapy to patients with locally advanced cervical cancer does not increase the toxicity of radiation reactions and the appearance of complications from critical organs and tissues. Chemoradiotherapy has been done to 298 patients with locally advanced cervical cancer IIB-IIIB tumor stage (T2b-3bN0-1M0) by developed methods of the complex conservative therapy. These methods are based on individual planning of radiotherapy on the criterion of not exceeding the level of tolerance for a normal tissues. Also there were evaluated the severities of general and local chemoradiation reactions from the «critical» organs and systems. The datas which represented in the article are indicating: the usage of radiomodifying doses of cytostatic medicaments during combined radiotherapy technologies that has been developed by us, do led to increasing of the number and severity of toxic effects just till 2nd level, but not over that value. Local application of hyaluronic acid, is safe and effective therapy to prevent and treat of the radiation-induced cystitis.
Keywords: cervical cancer, radiotherapy, critical organ and tissues, radiation reactions and complications.
2016, vol XXIV, #2, page 64
О. O. YEGOROV
Kharkiv Medical Academy of the Post-Graduate Education
Kharkiv Clinical Hospital on the Railways Nr. 2 Branch «Health Care Centre» of the Public Joint-Stock Company «Ukrainian Railways»
THE USE OF THE MAGNETIC RESONANCE TOMOGRAPHY IN STUDYING OF THE PLACENTA IN WOMEN, WHO UNDERWENT THE ORGAN-PRESERVING TREATMENT DUE TO EARLY MALIGNISATION OR INITIAL STAGES OF CERVICAL CANCER
Abstract. The aim of the study was to improve the diagnosis of the state of the placenta in women who become pregnant after organ-preserving treatment for precancer and early stages of cervical cancer.
Materials and methods. Magnetic-resonance-tomographic study of the placenta was performed 40 organ-pregnant after treatment for precancer and early stages of cervical cancer and 30 women with physiological pregnancy. Results and discussion. In women who have undergone organ-treatment for precancer and early stages of cervical cancer in the gestational age of 35 weeks, largely observed «III» the degree of maturity of the placenta, indicating that its premature aging.
Conclusions. Magnetic resonance imaging allows to evaluate not only the condition of the placenta, but also to monitor the primary cancer process.
Keywords: pregnancy, magnetic resonance tomography, placenta, cervical cancer.
2016, vol XXIV, #2, page 67
I.M. KIKHTENKO, M.I. KHVOROSTENKO, J.M. KHVOROSTENKO
State Establishment «Dnipropetrovsk Medical Academy»
INFLUENCE OF TISSUE INHOMOGENEITIES OF THE TUMOR ON THE QUALITY OF RADIATION TREATMENT PLANNING
Summary. We conducted a clinical study has shown the presence of tumor tissues sections of extremely small dimensions with pronounced heterogeneity in density. These sites are distributed spatially relative to each other of the type «honeycomb», when areas with a high density alternating with areas of low density. The small size, the nature of the spatial distribution, a large density gradient can create problematic conditions for realization of optimal radiation therapy plan.
Keywords: radiation therapy, optical density, pixel, voxel.
2016, vol XXIV, #2, page 73
Y. G. TKACHENKO
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
MODERN APPROACHES TO EARLY DIAGNOSTICS OF RECURRENCES OF THE DIFFERENTIATED THYROID CANCER
Summary. Various aspects of the differentiated form of thyroid cancer are reviewed: diagnostics, recurrences, methods of visualization and treatment, which were described in papers authored by Ukrainian and foreign specialists during the last decades.
Keywords: differentiated thyroid cancer, thyreoglobulin, radioactive iodine ablation, ultrasound diagnostics.
2016, vol XXIV, #2, page 80
L.VASILYEV, V. STARENKIY
SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
MODERN ASPECTS OF PRE RADIATION THERAPY PREPARATIONS OF PATIENTS WITH LUNG CANCER UNDERGOING CONFORMAL RADIATION THERAPY
Summary. In order to solve the main task of radiation therapy (RT) — maximum local detailed elaboration of tumor with minimal exposure to critical organs and tissues, the qualitative pre radiation therapy preparation which determines the effectiveness of radiation therapy treatment is very essential. The data from literature about main stages and features of clinical topometry during conformal external beam radiation therapy of patients with lung cancer is summarized in the present review.
Keywords: pre radiotherapy topometry planning, lung cancer, conformal external beam radiation therapy.
2016, vol XXIV, #2, page 87
N. V. KRASNOSELSKIY, G. V. KULINICH, A. T GONI SIMEKHA, T. V. KULCHAEVA
1SI «Grigoriev Institute for Medical Radiology of National Academy of Medical Sciences of Ukraine», Kharkiv
2 Kharkiv National Medical University
CLINICAL CASE OF RADIATION INJURY DUE TO ANGIOGRAPHY
Summary. Local radiation injuries may complicate the conduct of procedures in diagnostic and interventional radiology. In recent years there is an increase of radiation injuries due to more extensive use of them in cardiac surgery practice. In some cases, the cause of these complications may be explained by the individual characteristics of the patient, and by re-conduct of such intervention in one patient. We present a clinical case supervision of local radiation injury in cardiac surgery practice with repeated angiography and stenting.
Keywords: local radiation injuries, angiography, stenting.
2016, vol XXIV, #2, page 91
РЕЗОЛЮЦІЯ науково-практичної конференції з міжнародною участю «30 років з дня катастрофи на ЧАЕС: унікальний досвід та досягнення Харківського інституту медичної радіології у аварійному медичному реагуванні» (28-29 квітня 2016 р., Харків)
2016, vol XXIV, #2, page 93
НЕОНИЛА ОЛЕГОВНА АРТАМОНОВА, НИКОЛАЙ ВИЛЛЕНОВИЧ КРАСНОСЕЛЬСКИЙ
ГУ «Институт медицинской радиологии им. С. П. Григорьева НАМН Украины», Харьков
НАУЧНАЯ И ПРАКТИЧЕСКАЯ ДЕЯТЕЛЬНОСТЬ ВЫДАЮЩЕГОСЯ УЧЕНОГО ПРОФЕССОРА В. И. ШАНТЫРЯ
We are proud to announce the annual scientific conference of young scientists with the international participation, dedicated to the Day of Science in Ukraine. The conference will be held on 20th of May, 2016 and hosted by L.T. Malaya National Therapy Institute, NAMS of Ukraine together with Grigoriev Institute for medical Radiology, NAMS of Ukraine. The leading topic of conference is prophylaxis of the non-infectious disease in different branched of medicine.
Since 1993 the Institute became the founder and publisher of "Ukrainian Journal of Radiology”: