2003, vol XI, # 1
2003, vol 11, № 1, page 17
M.I. Spuzyak, O.P. Sharmazanova, N.S. Fokina, S.O. Hmizov, V.V. Skrebcov
Formation of distraction regenerate in children at elongation of lower extremities with the use of apparatuses for external fixation (clinical x-ray findings)
Objective: To study x-ray signs of the changes in formation of distraction regenerate at elongation of lower extremities in children with congenital and developed shortening and deformity, when monolateral bar apparatuses for external fixation are used.
Material and Methods: X-ray films of lower extremities before, during and after surgical correction of separate segments in 30 children (16 with congenital and 14 with developed deformities and shortening of the lower extemities) were analyzed.
Results: The association of the dynamics of reparation process in the bone tissue and the cause of the shortening (congenital or developed) and the age of the patients was revealed. The dynamics of regenerate formation in the early and late terms after the surgery as well as the changes in Barnette-Nordin index during the treatment were analyzed.
Conclusion: The term of formation of distraction regenerate in patients with congenital shortening and deformities is longer than in patients with developed pathology. Beginning of regenerate development, when monolateral bar apparatuses for external fixation are used, is more active on the side opposite to the apparatus.
Key words: regenerate, distraction, shortening of the extremities, bar apparatus.
2003, vol 11, № 1, page 21
Roentgenogrammetry in diagnosis of age-dependent changes of the bone tissue
Objective: To study age-dependent aspects of the clavicle using roentgenogrammetry as well as to develop clavicle indices and to determine the criteria for evaluation of age-dependent changes in men and women for forensic medical identification.
Material and Methods: Roentgenogrammetry was used to analyze 120 x-ray films of the right clavicle obtained at autopsy of female and male corpses aged 20 - 80 who died without the signs of the diseases influencing bone tissue metabolism. X-ray study of the bones was done in the position on the lower surface. The following parameters were measured: the width of the diaphysis, the width of the bone-marrow cavity in the area of the diaphysis, the length of the clavicle. The technique for determining clavicle index based on modified Barnett-Nordin technique and Baizuldina's technique was worked out. The obtained mean values of clavicle index were studied and analyzed for each of the 6 groups.
Results: It was determined that the indices of the x-ray film correlated with the age-dependent changes in the bone tissue which occurred due to involution osteoporosis and could be of practical value for personality identification in forensic medical expertise.
Conclusion: Significant information about x-ray morphological changes in the bone tissue of the clavicle in involution osteoporosis was obtained. The criteria for assessment of the clavicle age were established. These results can be used for personality identification in forensic medical practice for judgment about the age using the bone remnants.
Key words: roentgenogrammetry, clavicle, involution osteo porosis, forensic medical identification, age.
2003, vol 11, № 1, page 25
Principles of osteoarticular tuberculosis radiodiagnosis
Objective: To improve the efficacy of osteoarticular tuberculosis radiodiagnosis.
Material and Methods: The findings of examinations with the use of radiodiagnosis techniques of 1632 adult patients with the pathology of musculoskeletal system (of them, 52% with the lesions of the spine and 48% with joint diseases) treated at Kharkiv Regional Tuberculosis Hospital in 1995-2000 were studied.
Results: Both generally accepted and up-to-date techniques (CT, MRI, bone scan, US) were used. The investigation of the patients with spine pathology revealed tuberculous spondylitis in 72% of them. In joint lesions, tuberculosis was diagnosed in 79% of cases. The rest had non-specific inflammatory processes, various osteodystrophies, cancer.
Conclusion: To diagnose osteoarticular tuberculosis a complex of radiodiagnostic techniques should be used, x-ray study being the basic one.
Key words: radiodiagnosis of osteoarticular tuberculosis, x-ray tomography, computed tomography, magnetic resonance imaging.
2003, vol 11, № 1, page 31
V.I. Choban, G.V. Cvigun, D.S. Мechev, V.G. Polegaev
Scintigraphy of skeleton with labeled phosphates in diagnosis of early destructive changes of locomotor system with stress fracture
bjective: To assess the role of bone scan in the military men with stress fracture and to study the peculiarities of early bone stress.
Material and Methods: Seanning was used to investigate 105 military men with skeleton stress fracture, aged 18- 25. A bolus intravenous injection of 800 MBq of 99mTc-pyrophosphate in 0,5 to 1 ml of normal saline was made. The investigation was carried out on gamma-camera MB-9100 ( Hungary ) equipped with a computer processor "Migra" (Kyiv) at 1 shot in 1 s. interval. The technique involved two stages: the first one in the phase of blood flow during 240 s resulted in the overall scintigraphy shot of only one projection of interest. The second stage in the phase of the optimum ratio of the RP accumulation in the soft tissues and bones in 3-4 hours enabled to carry out polypositional investigation. Qualitative and quantitave assessment of RP passage at the stages of arterial inflow, microcirculatory blood flow and venous outflow as well as static quantitative scintigraphy in the phase of tissue maximum blood pool at the end of the 240 th s was made. In 3-4 hours the changes in the skeleton at the bone metabolism level were scintigraphically determined.
Results: Angioscintigraphic variants of separate and combined pictures of blood flow changes and skeleton rebuilding were singled out; the extent of disorders of indices at different stages of rebuilding process was determined.
Conclusion: High diagnostic value and availability of dynamic and static scintigraphy of skeleton allow to recommend this method for detection of functional disorders in blood flow and early changes of bone metabolism as the method of screening and monitoring of stress fracture.
Key words: radionuclide study, locomotor system, angio-scintigraphy, static scintigraphy, stress fracture of skeleton.
2003, vol 11, № 1, page 36
S.G. Мazur, I.I. Glazovskay, V.V. Kuznecov
Characteristics of brain circulation in patients with vertebral artery hypoplasia in stenoocclusive lesions of carotid arteries
Objective: Comparative analysis of peculiarities of brain csrculation in persons with vertebral artery hypoplasia depending on atherosclerotic lesions of the carotid arteries.
Material and Methods: 102 patients were examined: 44 posts-troke patients (of them -19 with vertebral artery hypoplasia), and 58patients without the signs of carotid stenosis (of them - 31 with vertebral artery hypoplasia). The following indices were measured and determined by of Color Duplex Sonography and Transcranial Color Duplex Sonography: the vessel diameters, blood flow velocities, volume blood flow velocities, total cerebral volume blood flow.
Results: Post-stroke patients with vertebral artery hypoplasia had a lower grade of carotid stenosis compared with post stroke patients without vertebral artery hypoplasia. Total cerebral volume blood flow in thepoststrokepatients with vertebral artery hypoplasia was less compared with the poststroke patients without vertebral artery hypoplasia. But in the same time there were no differences in total cerebral volume blood flow values between healthy persons with and without vertebral artery hypoplasia.
Conclusion: Vertebral artery hypoplasia in patients with cerebral atherosclerosis evokes decompensation of cerebral hemo-dynamics and causes ischemic stroke with a lower grade of carotid stenosis than that in patients without vertebral artery hypoplasia.
Key words: color duplex sonography, stroke, carotid stenosis, vertebral artery hypoplasia.
2003, vol 11, № 1, page 40
The use of radiochemical analysis for detecting biotracers of food radioactive contamination in Cherkasy Region
Objective: To determine stable biotracers of radioactive contamination according to the findings of analytical control of the foodstuffs as well as to evaluate the use of radiochemical analysis for determining the activity of the foodstuffs and water (Sr-90, Cs-137).
Material an d Methods: The study of radionuclide activity in the foodstuffs was done with scintillation and radiochemical analysis using computed unit УСК Gamma Plus (Expertcentr, Moscow ).
Results: The analytical findings proved that in Cherkasy region the most sensitive to insignificant changes in the radioactive background of Sr-90 were the cattle bones and fish caught in Kremenchug water reservoir, that of Cs-137 - milk.
Conclusion: While detecting biotracers of radioactive contamination at foodstuff control, it is necessary to pay attention to the above mentioned kinds of foodstuff. It will allow to react quickly to the contaminating factor and can assure quality of contamination monitoring. The use of radiochemical analysis allows to obtain a more accurate measurement readings, reduce the time of sample preparation and save energy resources.
Key words: biotracers, strontium-90, cesium-137, radiochemical analysis.
2003, vol 11, № 1, page 44
B. Dashkevichene, V. Mamontovas
Peculiarities of multiple sclerosis signs in CT and MR images. Its diagnosis in Lithuania
Objective: To analyze CT and MRI sings of multiple sclerosis (MS) as well as to compare these diagnostic techniques with other methods of examination.
Material and Methods: MRI was performed in 196 patients aged 10—60, of them 128 women and 68 men, at Tomography Department of Vilnius University using Siemens Magneton Symphony (1.5T) unit. Tl, T2, T2 dark fluid and PdT2 sagittal, transverse and coronal images were obtained. MRI was done with and without intravenous injection of paramagnetic contrast substance (Omniscan, Nycomed Amersham and Magnevist, She- ring) 0.1—0.2 ml/kg of body mass. CT was used to study 20 patients. Liquor IgG amount was determined, the liquor was investigated using oligocloned bands, the patients were and performed investigation of somatosensor potentials on the central beams.
Results: The investigation determined the foci of demyelinization in 97 of 196 patients. The study of the craniocervical portion of the spine in 29 patients revealed the foci of demyelinization in 5 patients.
The diagnosis was verified in 49 patients. The findings of the examination allowed to distinguish the following forms of the disease: primary progressing - 25, secondary progressing - 9, remitting progressing - 3, remitting relapsing - 11 patients.
A separate variety of MS in children was revealed (1 case).
Conclusion: The most accurate method of MR diagnosis is MRI. Comparison of clinical data proves that CT is notreasonable as this method is not sufficiently informative.
Key words: multiple sclerosis, CT and MRI diagnosis.
2003, vol 11, № 1, page 49
G.S. Efimova, S.A. Amirazyan, A.M. Nasonova
Cardiovascular complications at mediastinum irradiation for Hodgkin's disease
Objective: To study the state of cardiovascular system and to reveal risk factors of cardiovascular pathology during and after complex treatment for Hodgkin's disease.
Material and Methods: The study involved 52 persons (27 men and 25 women) who were administered radical radiation therapy involving medistinum. The majority of them also received a course of polychemotherapy. All the patients were divided into two groups: general and cardiac ones. The patients had II-III stage disease of various cytological types. Mean age of the patients was 49.8, 37.1 and 58.4 in the general and cardiac group, respectively.
General examination included clinical examination, deter mining cholesterol level, chest x-ray, veloergometry, echocardio- graphy with investigation of systolic and diastolic functions.
The patients were administered Co-60 gamma-irradiation (45 Gy in 20-22 fractions). According to the calculations, the irradiated volume of the heart did not exceed 50% of its size.
The protocols of chemotherapy did not include cardiotoxic drugs, except for adriamicyn, but total dose did not exceed 300 mg/m2.
Results: Increase of the incidesnce of negative dynamics of coronary artery disease was noted in the cardiac group. At the beginning of the treatment negative changes were noted in 15% of the patients, by the end of the treatment — in 25 % .
Fatal ischemia, sudden death, valvular sclerosis and severe circulatory insufficiency were not registered.
Conclusion: Irradiation of considerable volumes of the cardiac muscle during radiation therapy is a risk factor and is accompanied by statistically insignificant aggravations in the state of the patients with cardiac diseases. The study proved negative influence of traditional risk factors on the state of cardiovascular system during and after complex treatment.
Key words: Hodgkin's disease, radiation therapy, risk factors, cardiovascular system.
2003, vol 11, № 1, page 53
Y.O. Vinnik, M.Y. Neffa, T.V. Skricka
Influence of different varieties of pre-operative chemotherapy on the hormonal status of the patients with ovarian cancer
Objective: To study and compare the changes in the hormonal status of the patients with ovarian cancer (ОС) at combined treatment with the use of different variants of pre-operative chemotherapy (CT).
Materials and Methods: Eighty-eight patients with ovarian cancer were divided into 2 groups: group 1 — 46 patients who were administered pre-operative intravenous chemotherapy, group 2 — 42 patients, in whom combined treatment was started with intraperitoneal CT chemotherapy. Intraperitoneal chemotherapy was administered 48 hours prior to surgery with the use of cisplatinum at a single dose of 100 mg/m2 in combination with intravenous injection of cyclophosfamide at a single dose of 600 mg/m2 . Intravenous chemotherapy was administered according to the same protocol 21 days prior to surgery. CT course was preceded by cytology diagnosis. Radioimmunological assay was used to deter mine T3, T4, TTH, cortisol, insulin and prolactin blood serum concentration before the treatment, after chemotherapy, on the day of the operation, on the 1st , 4th and 10th days after the operation.
Results: General regularities of the changes in the contents of hormones irrespective of the way of chemotherapy administration, which are characterized by reduction in T3 level, increase of TTH, cortisol and prolactin concentration, were determined. Significant differences in the amount of some hormones were revealed though general regularities of the hormonal status changes did not change. Thus, cortisol level increased 1.3 times and that of insulin increased 2.3 times in the patients who underwent pre-operative intravenous chemotherapy .
Conclusion: Combined treatment with application of pre-operative intraperitoneal chemotherapy has less expressed stress influence on the organism of the patients with ovarian cancer in comparison with administration of pre-operative intravenous chemotherapy.
Key words: ovarian cancer, intraperitoneal chemotherapy, hormonal status, intravenous chemotherapy.
2003, vol 11, № 1, page 58
N.I. Afanaseva, O.V. Mugichuk
Thyroid hormone state and hypophysis thyrotropic function in patients with thyroid cancer accompanied with benign thyroid pathology
Objective: To study the state of hormonal homeostasis in patients with thyroid cancer (TC) and benign thyroid pathology (BTP).
Material and Methods: The amount of thyroid hormones (T3, T4) and TTH was evaluated in patients with TC and autoimmune thyroiditis (AIT) (group 1 — 20 women); CT and nodular goiter (NG) (group 2-16 women), TC and colloid goiter (CG) (group 3-32 patients, of them 30 women and 2 men). The patients were compared with the groups suffering from CT (group 4-30 women), AIT (group 5—72 patients, of them 60 women and 12 men), NG (group 6 — 64 patients, of them 59 women and 5 men), CG (group 7 — 51 women) and healthy subjects (group 8 - 5-o women).
T3, T4, TTH amount was studied with the use of standard RIA kits (IMMUNOTECH, Czech republic ), statistical evaluation of the data was done with STATISTICA software.
Results: The analysis of thyroid hormone state and TTH amount in patients with TC accompanied by AIT, NG, CG suggested the presence of laboratory hypothyroidism, which was more pro nounced in patients with concomitant CT and AIT, CT and NG.
Conclusion: The presence of BTP (AIT, NG, CG) can make a background for laboratory hypothyroidism when is not treated adequately, which can stimulate development of neoplastic process. The most unfavorable background causing thyroid cancer is autoimmune thyroiditis and nodular goiter. The course of these diseases can disguise thyroid cancer and be a cause of prolonged inadequate drug therapy and diagnosis of thyroid cancer. Hormone therapy of nodular BTP must be suppressive, not substitutive.
Key words: combined thyroid benign and malignant pathology, thyroid hormones, TTH.
2003, vol 11, № 1, page 63
The changes in the structure of rat erythrocyte membrane under the influence of Guerin's carcinoma after fractionated irradiation and sodium succinate administration
Objective: To study the biophysical aspects of the state of erythrocyte membranes on experimental models of Guerin's carcinoma at local fractionated x-ray irradiation of the organism in combination with sodium succinate action.
Material and Methods: The effect of local fractionated x-ray exposure at a total dose of 14 and 32 Gy and sodium succinate (100 and 400 mg/kg) administered 1 hour before exposure was studied in 48 rats weighing 160-180 g which were injected 20% suspension of Guerin's carcinoma cells subcutaneously. Electrolytic parameters of the membranes, resistance of the erythrocytes to acid hemolysis, index of the cell shape, the amount of electrolytes in the blood plasma and erythrocytes were studied on the 21st and 25th days.
Results: Increase in the relative conduction, reduction in breakdown strength of current, disturbances in the electrolyte balance of potassium and sodium in the plasma and erythrocytes, significant changes in the index of the cell shape were observed in the rats with tumors when compared with the controls. The amount of sodium in the erythrocytes remained increased at local x-ray exposure of the site of Guerin's carcinoma cell transplantation and sodium succinate action which was manifested by considerable widening in the volume of erythrocyte histogram and increased values of relative conductivity of the cells. Acid hemolysis indices become equal.
Conclusion: When a tumor is present, the population of erythrocytes becomes heterogeneous. Sodium succinate produces membrane-stabilizing effect on the cells of the hemopoietic system.
Key words: erythrocyte membranes, Guerin's carcinoma, electric break-down, relative conductivity, hemolysis rate, shape index.
2003, vol 11, № 1, page 68
Long-term disorders of memory in the persons survived acute radiation sickness due to Chornobyl accident
Objective: To evaluate the state of the memory in the persons survived acute radiation sickness (ARS) due to Chornobyl accident.
Material and Methods: The study involved two groups of the patients: main group - 52 men survived ARS aged 35-55, cont rols - 23 healthy men aged 36-55. Clinical neuropsychological methods were used (methods of Luria, Wasserman, Ray). Auditory and visual memory was studied.
Results: Statistically significant, when compared with the controls, reduction in memorizing series of words was revealed in the main group. Considerable changes were observed in the study with interference. Delayed reproduction was considerably lower when compared with the controls. Reduction of the short-term memory was not revealed but visual disturbances were seen in the study with interference. Long-term visual memory was preserved.
The study demonstrated the signs of disturbances in the left temporal region in the form of elements of acoustic mnestic aphasia, signs of disturbances in the higher forms of regulation in the form of control defects, programming mnestic activity as well as the signs of disturbances in the dynamic components of mental activity in the form of increased braking of the traces at inter ference.
Conclusion: The obtained results suggest that the changes in the structure of the anterior portions of the brain which are responsible for obtaining, processing and reproduction of verbal information, namely the cortex of the left temporal and frontal regions with their cortical-subcortical associations, play the leading role in the memory disorders in persons survived ARS.
Key words: acute radiation sickness, memory, neuropsychology.
2003, vol 11, № 1, page 73
R.I. Kratenko, A.B. Mitryaev
Influence of ionizing radiation and 12-crown-4 on receptor apparatus and second messenger system in rat neocortex
Objective: To investigate the state of adreno- and serotonin receptors as well as cyclic nucleotides system in neocortex of rats exposed to ionizing radiation and 12-crown-4.
Material and Metods: The binding parameters of 3 H-serotonin, 3 H-spiperone - 5HT1- and 5HT2-receptor selective ligands and of 3 H-WB4101 and 3 H-dihydroalprenolole - selective ligands of oCj- and p-adrenoreceptors were established with radioligand method in synaptosome membranes of rat neocortex. Cyclic nucleotide system state was evaluated according to cAMP and cGMP contents and activity of adenylate-, guanylatecyclase and phosphodies- terase in rough membrane fraction of neocortex.
Results: Increase in oCj-adrenoreceptor affinity and decrease in their quantity in rats exposed to radiation and toxified by 12-crown-4 compared to the control was observed. Increase in p-adrenoreceptor affinity and quantity of the animal experimental groups was registered. The affinity of 5-HTl-receptors of expe rimental rats was elevated by 24-36 % , the binding site quantity diminished by 16-21 %. The adenylatecyclase activity reduction correlated with decrease in cAMP contents of animals toxified with 12-crown-4 (-42 %) and of exposed animals (-50 %). 12-crown-4 and ionizing radiation action resulted in the induction of guanylatecyclase activity by 86 % and 66 %, respectively, and in the elevation of cGMP contents by 82 % and 66 %, respectively, compared with the control. The phosphodiesterase activity of the animals of both experimental groups was higher than the control figure by 146 % and 67 % accordingly.
Conclusion: Action of 12-crown-4 and ionizing radiation results in the alterations of receptor affinity and quantity, the activity of cyclic nucleotide synthesis and catabolism enzymes, cAMP and cGMP contents. 12-crown-4 and ionizing radiation influence has a non-specific modulating character and may be realized via evoked conformational changes of membrane receptory and protein complexes, via stimulation of membrane lipid peroxidation process, modification of membrane protein phospholipid microsurrounding, ionic disbalance of cells. The alterations of receptory and cyclic nucleotide systems in the action of 12-crown-4 and ionizing radiation are a cause and reflection of dismetabolic phenomena.
Key words: crown ethers, ionizing radiation, adrenoreceptors, serotonin receptors, neocortex, adenylatecyclase, guanylatecyc lase, cyclic nucleotides, phosphodiesterase.
2003, vol 11, № 1, page 78
V. Е. Orel, N.M. Dzyatkovskay, M.Y. Danko, Y.R. Мedinec, V.A. Zinchenko, S.V. Andriychenko, Y.М. Bilokin, A.V. Romanov, O.Y. Pridatko
The effect of 40 MHz electromagnetic irradiation and mechanically activated doxorubicin on animals with carcinosarcoma Walker-256
Objective: To study the influence of 40 MHz electromagnetic irradiation (EMI) and mechanically activated (MA) doxorubicin (DR) on animals with carcinosarcoma Walker-256.
Material and Methods: The investigation was carried out on 60 mongrel male rats weighing 90-100g. Local 20 min 40 MHz EMI of animals was carried out by frame at intensity of absorbed energy of 5.2 mW/cm 3 . Mechanical activation of the solid state of the drug was performed in the microvibromill with mechanical energy 20 W/g for 5 min. The drug was infused intraperitoneally at a dose of 1 Mg/kg on the 3rd, 5th, 7th days and 3 Mg/kg on the 11th and 13th days after of the tumor transplantation. The changes in the tumor volume, malonic dialdehyde (MDA) level, catalase and superoxide dismutase (SOD) activity in the tumor, serum chemiluminescence (CL) and mechanoemission (ME) of blood were studied. This was accompanied by cytologic investigations of the tumor.
Results: It was shown that in the group of animals exposed to EMI, increase of the tumor volume occurred. Combination of EMI with MA drug had more pronounced anticancer activity. In mali gnant cells, numerous necrosis parts, increase of destruction and heterogenous cells were noted. After combined influence of EMI and MA DR MDA level, catalase and SOD activity in tumor, serum CL and ME in animal blood were decreased.
Conclusion: Combination of 40MHz EMI and MA DR at physiologic temperature initiates the greatest inhibition of the tumor growth, the lowest mitotic index and changes in the intensity of peroxide oxidation in carcinosarcoma Walker-256 and the blood of animals in comparison with monotherapy using officinal DR, 40MHz EMI and their combination action.
Key words: electromagnetic irradiation, mechanical activation, doxorubicin, carcinosarcoma Walker-256, peroxide oxi dation.
2003, vol 11, № 1, page 83
E.М. Gorban, N.V. Topolnikova
Influence of Spirulina on the endocrine status and lipid peroxidation processes in irradiated rats
Objective: To study the influence of blue-green seaweed Spirulina platensis (SP) on the endocrine status and lipid peroxidation (LP) in the liver, kidneys and heart of rats one month later single x-ray exposure.
Material and Methods: The experiments were conducted on Wistar male rats aged 8 mo. Group 1 - controls; group 2 - animals taken into experiment 1 month after single irradiation at a dose of 2 Gy; group 3 - the rats fed for 1 month with SP at a dose of 500 mg/kg of body mass daily; group 4 - animals after single irradia tion fed for 1 month with SP. Intensity of 11-oxycorticosteroids (11-OCS) basal secretion by isolated adrenal glands (AG), reac tivity of isolated AG on ACTH, levels of insulin and thyroxin (T 4 ) in the blood were determined. To study LP, the levels of malonic dialdehyde (MDA), catalase (Cat) and superoxide dismutase (SOD) activity was measured in the liver, kidneys and heart.
Results: X-ray exposure did not change basal secretion of 11- OCS by isolated AG and blood insulin level; the level of T 4 in the blood and that of MDA in the liver and kidneys was increased; reactivity of AG on ACTH, Cat activity in the kidneys and heart as well as SOD activity in kidneys were decreased. Feeding with SP did not change the investigated parameters. In the group of irra diated animals fed with SP, reactivity of isolated AG on ACTH, levels of T 4 and MDA in the blood and SOD activity in the kidneys was not different from the control levels.
Conclusion: The findings of the research demonstrate the efficacy of SP in correction of radiation impairment of AG glucocorticoid function, radiation increase of thyroxin and MDA levels and prevention of inhibition of organism antioxidant protection in rats exposed to ionizing radiation.
Key words: Spirulina platensis, endocrine status, lipid peroxidation, radiation, rats.
We are proud to announce the annual scientific conference of young scientists with the international participation, dedicated to the Day of Science in Ukraine. The conference will be held on 20th of May, 2016 and hosted by L.T. Malaya National Therapy Institute, NAMS of Ukraine together with Grigoriev Institute for medical Radiology, NAMS of Ukraine. The leading topic of conference is prophylaxis of the non-infectious disease in different branched of medicine.
Since 1993 the Institute became the founder and publisher of "Ukrainian Journal of Radiology”: