Home » Ukrainian Journal of Radiology » 2002, vol X, # 2

2002, vol X, # 2

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2002, vol 10, № 2, page 117

O.V.Garnyuk V.I.Evdokimov

The role of ultrasound study in diagnosis and cryosurgical treatment of chronic tonsillitis

Annotation

Objective: To study the capabilities of ultrasound study in diagnosis and treatment of chronic tonsillitis.

Material and Methods: Ultrasound study of tonsils was done in 126 patients with chronic tonsillitis before and during cryotherapy according to the original technique with visualization of the process of the freezing front movement in the real-time mode.

Results: Due to the ability to visualize with ultrasound, various sizes of tonsils were revealed and analyzed in vivo. Ultrasound structure of the tonsils at chronic inflammation as well as presence of different inclusions and dense capsule of the tonsils were determined which was in accordance with the results of pathomorphological study of the removed tonsils in chronic tonsillitis. Owing to visualization of the process of freezing of the tonsil, the factors influencing the process of cryotherapy were revealed.

Conclusion: Ultrasound study of tonsils can and should be used at examination of the patients with chronic tonsilitis as an essential additional diagnostic technique. Ultrasound study of tonsils at cryotherapy has several advantages over “blind” cryotherapy.

Key words: ultrasound study, chronic tonsillitis, cryotherapy.

2002, vol 10, № 2, page 120

G.V.Vazenina

Characteristic of structural changes in the brain of patients with chronic disturbances of the brain circulation of hypertension origin of different stages

Annotation

Objective: To study the structural changes in the brain of the patients with chronic disturbances of brain circulation (CDBC) of different degree caused by hypertension disease using MRI findings.

Material and Methods: The study involved 112 person with different stages of chronic cerebrovascular pathology: with initial manifestation of cerebral circulation insufficiency and dyscirculatory encephalopathy (DE), stage 1 — 30, stage II — 60, stage III — 22 persons. The disease was caused by stage I-II hypertension disease, lasting for 3-20 years.

All patients were performed brain MRI with the use of T1- and T2 weighted images.

Results: In patients with stage I CDBC the state of the brain structures did not differ from that in healthy persons, of them 26.6% had changes in the liquor-containing spaces of different degree. The sings of brain substance atrophy (widening of the ventricles and subarachnoid spaces) were registered in 58.8% of stage II CDBC. Progression of CDBC was accompanied by the appearence of foci of low density or diffuse reduction in the density on T1-weighted images. In patients with stage III CDBC, the signs of atrоphy increased (81.8% of patients). There was a distinct tendency to preliminary increase in the ventricular system to the left, structural changes in the brain substance in the form of solitary, (31.8% patients) and multiple, (36.4% patients) foci of decreased density, chiefly localized in the deep portions of the brain. In 22.7% of patients there were sings of leucoareosis.

Conclusion: With the development of DE, structural changes increase. The size of the brain ventriclres and subarachnoid spaces enlarges, the incidence and degree of atrophy increases; solitary cystic focal changes in the brain become multiple.

Key words: chronic disturbances of brain circulation, hypertension disease, magnetic resonance imaging.

2002, vol 10, № 2, page 125

O.A.Mihanovskiy

Analysis of the efficacy of combined and radiation therapy for uterine body cancer

Annotation

Objective: To evaluate the efficacy of combined and radiation treatment for uterine body cancer (UBC) as well as to study the dependence of the development of relapses and metastases and their localization and the term of occurrence, the type of therapy, disease stage and histology of the tumor.

Material and Methods: Long-term results of combined and radiation treatment of 215 patients with UBC were studied. Of them, 166 patients received combined treatment (group 1) and 33 were administered radiotherapy (group 2). The patients from group 1 were performed uterus and adnexa extirpation. After the surgery they were done distance gamma-therapy (DGT) using ROCUS-M unit. In T2 NO MO UBC they were also performed irradiation of the vaginal scar using AGAT unit. DGT in patients with UBC treated by irradiation was also performed using ROCUS M unit. Intracavitary radiotherapy (RT) was carried out using AGAT B unit.

Results: Five-year survival of the patients with UBC treated by combined technique was 81.3%, that in the patients treated by radiation 57.6%. In 26 patients (84%) of group 1, relapses and metastases occurred within the first three years after the operation. The majority of them, 54.4% (18 patients) were revealed within 1 year after the surgery. In group 2, all relapses and metastases developed within 3 years after the end of the treatment. As in group 1, the majority was diagnosed within the first year, 78.6% (11 patients). In the both groups, direct correlation between the incidence of relapses and metastases, stage of the disease and the degree of differentiation of endometrial adenocarcinoma. The relapses of the disease in group 1 were most frequent on the vaginal scar, 42.0% (13), in group 2 in the uterus on the site of the primary tumor, 71.4% (10). In patients from group 2, when the length of the uterine cavity was more than 8 cm, relapses and metastases were 2 times more frequent than in the patients with its length equal or less than 8 sm.

Conclusion: Combined treatment for UBC is more effective that RT with a linear technique, as their 5-year results are 20% better. More frequently relapses and metastases develop in T2NxMo and T3NxMo tumors, low-differentiated endometrial adenocarcinoma and in patients with the length of the uterine cavity exceeding 8 cm. Main causes of failure of combined treatment are relapses of the diseases in the vaginal scar, that in RT are relapses in the uterus. The majority of relapses and metastases in UBC occur within the first 3 years after treatment. Improvement of the surgery ablation and that of the Intracavitary RT are main ways to increase the efficacy of combined and radiation treatment for UBC.

Key words: uterine body cancer, combined treatment, radiotherapy.

2002, vol 10, № 2, page 130

I.M.Krugova

Capabilities of comparative evaluation of the efficacy of different methods and stages of ovarian cancer treatment using tumor-associated marker CA-125

Annotation

Objective: To analyze immediate results of different schemes and stages of anti-tumor treatment (ATT) in patients with ascitic form of ovarian cancer (OC) using evaluation of the level of tumor-associated CA-125 marker.

Material and Methods: Eighty-four patients with stage I - IV ascitic OC were studied at Grigoriev’s Institute for Medical Radiology in 1995–2001. The study was done before treatment, after treatment and once a month during different stages of treatment.

Results: On the basis of the study of CA-125 levels before and after a definite stage of ATT, it is suggested to calculate efficacy coefficient (KE) which can help to perform comparative evaluation of the efficacy of different schemes and stages of treatment. The use of the suggested method allowed to prove the expediency of cytoreductive operations in treatment of ascitic OC. The use of the tumor marker CA-125 and evaluation of the degree of its reduction with calculation of efficacy coefficient at different stages of ATT allowed to prove the efficacy of radiotherapy in complex treatment of ascitic OC.

Conclusion: The suggested coefficient which takes into consideration not only the fact of reduction of CA-125 level but also reflects numerically the degree of the process can be recommended for comparative evaluation of the efficacy of different protocols and stages of ascitic OC treatment.

Key words: ascitic ovarian cancer, radiotherapy, tumor-associated CA-125 marker.

2002, vol 10, № 2, page 134

V.O.Rogozin, E.M.Bozok, M.I.Pilipenko

Algorithm of interventional radiological markers application to pre-operative diagnosis of breast cancer

Annotation

Objective: To study and evaluate the capabilities of invasive radiological techniques in pre-operative diagnosis of breast cancer and to work out the algorithm for its application.

Material and Methods: The study involved 262 patients aged 17 - 90 who were diagnosed pathological breast neoplasms at complex clinical x-ray and ultrasound investigation. The following interventions were performed to make differential diagnosis before surgery: ductography, pneumocystography, guided fine-needle aspiration biopsy (FNAB), guided transcutaneous thick-needle biopsy (trepan biopsy).

Results: Diagnostic capabilities of invasive radiological techniques in pre-operative diagnosis of breast cancer were studied. The findings of the complex study of 262 patient were analyzed using the above invasive procedures.

Conclusion: The use of invasive techniques at pre-operative stage allowed to make the diagnosis of malignant tumor in 101 patients (38.5% of the investigated persons). The algorithm for application of invasive techniques under visual control was worked out.

Key words: breast cancer, guided biopsy, ductography, pneumocystography, algorithm

2002, vol 10, № 2, page 138

S.A.Amirazyan, J.A.Tolkachov, S.I. Rozdilskiy, A.S.Rozdilskaya

Correction of some cardiovascular disorders at radiotherapy for breast cancer

Annotation

Objective:To study the capabilities and expediency of preventive therapy of the most common disturbances in the cardiovascular system at radiotherapy for breast cancer with the purpose to improve the quality of life in cancer patients.

Material and Methods:The study involved 43 patients aged 31 Њ 62. The study was performed during combined treatment of cancer of left breast and included ECG and tetrapolar rheography followed by computed and statistical processing with the methods of non-parametric statistics with the use of STATISTICA software. To correct the observed tachyarrhythmia and the changes in the central hemodynamics, calcium antagonists were administered to 20 patients.

Results: Increase in the number of tachyarrhythmias from 16 to 41 %, occurrence of extrasystоlia in 20 % of patients were revealed against a background of radiotherapy. In several cases the indices of the central blood flow (stroke and minute volumes, cardiac index) were decreased and total peripheral resistance of

vessels was increased. The patients who received calcium antagonists survived the treatment better; the heart rate reduced by 10 %, stroke and minute volumes were at their initial level or increased by 20 %, total peripheral resistance decreased by 23 % when compared with the controls. The parameters of hemodynamics differed significantly in the both groups before the special treatment and after it (p<0.015 for all indices, except minute volume and peripheral resistance, the difference between them was insignificant).

Conclusion: Therapy with calcium antagonists which is started in the middle of the distant radiotherapy course prevents the changes in the cardiovascular system in 95 % of cases and allows to improve the quality of life which is especially important for the patients who have already had various (especially ischemic) cardiac

disturbances.

Key words: breast cancer, radiotherapy, cardiovascular system, calcium antagonists. Correction of some cardiovascular disorders at radiotherapy for breast cancer

2002, vol 10, № 2, page 142

O.I.Butrim, V.V.Tsvetkova, V.V.Novopashennaya, V.V.Kondratyuk

On the technique of distant irradiation of brain astrocytomas

Annotation

Objective: To evaluate the capabilities of post-operative radiotherapy (RT) in patients with brain astrocytomas (BA) with local irradiation using Teratron-780 C unit.

Material and Methods: Thirty-six patients with BA were administered post-operative gamma-therapy using Teratron-780 C unit (SSD = 80 cm, exposure dose 254–150 R/min with 2 Gy fractions, total focal dose 50–60 Gy. The irradiation fields included the bed of the tumor (according to pre-operative size of the tumor) + 1 cm margins.

Before the irradiation the patients were done CT- or MRI and topometry using computer planning unit Theroplan-Plus.

Results: Long-term findings demonstrated 2-year survival and good and satisfactory quality of life in 81 % of the patents in whom total excision of the BA had failed. In patients who were followed up for 5 years, CT study revealed calcinates in the area of the irradiated residual tissue of BA.

Conclusion: Post-operative RT is an important part of BA treatment. The technique for local irradiation of BA depends largely on capabilities of pre-irradiation examination and availability of modern radiotherapy equipment.

Key words: brain astrocytoma, local post-operative radiotherapy, pre-irradiation preparation.

2002, vol 10, № 2, page 145

O.Z.Gnateyko, Z.M.Fedopishin, N.I.Kitsera

Investigation of the changes in the frequency of congenital development anomalies

after Chornobyl accident in Rivno Region

Annotation

Objective: To study the dynamics of congenital development anomalies (CDA) in contaminated districts of Rivno Region when compared with the controls, Lviv Region.

Material and Methods: Non-randomized retrospective analysis of newborn registries of the maternity hospitals. The data were processes using the methods of variation statistics.

Results: A year before the Chornobyl accident (1985) a low level of the frequency of congenital development anomalies was registered both in Rivno and Lviv Regions. The incidence of CDA in 1986 – 2000 was 195.13±73.06 per 10,000 in Rivno Region and 247.04±107.93 in the controls. The difference is insignificant (p>0.05). In the both populations, dynamic increase of the incidence of CDA due to their frequency and musculoskeletal system deformities as well as CDA of the reproductive system was noted. Significantly higher incidence of polydactyly and minor CDA was revealed in the investigated region was noted, the frequency of reduction defects of the extremities and Down’s syndrome did not differ in the both groups.

Conclusion: The data which prove the correlation of the frequency of CDA and mutations in the contaminated districts were not obtained.

Key words: congenital development anomalies, newborns, radioactively contaminated districts, Rivno Region, Lviv Region.

2002, vol 10, № 2, page 148

O.O.Bobilova, L.I.Simonova, V.Z. Gertman

The state of lipid metabolism in liquidators at long terms after the accident

at Chornobyl Atomic Power Plant

Annotation

Objective: To study state of lipid metabolism in the participants of the Chornobyl accident clean-up at long term after the accident.

Material and Methods: The spectrum of lipids in the blood serum in 202 men aged 35–55 who participated in the Chornobyl accident clean-up. All of them worked at the plant in 1986–1987 and receive total dose of 10–25 cGy. All the patients were divided into two age groups, 35–44 years old and 45–55 years old. Lipid spectrum was studied by determining and calculation of the following parameters: total cholesterol, triglycerides, high, low and very low density lipoproteins, cholesterol atherogenicity coefficient.

Results: The comparative analysis demonstrated stable changes in the lipid metabolism characterized by considerable increase in atherogenic lipoproteins (low and very low density), cholesterol and triglycerides against a background of reduction of antiatherogenic lipoproteins (types IIa, IIb, IV of lipidemia not characteristic for this age group)   in 66 % of patients from the younger age group (35–44 years old), which were observed for 10–15 years after the accident. In 60 % of the investigated patients aged 45–55 the disturbances in the lipid spectrum were less pronounced (type IIa of lipidemia), though their frequency 3.5 times exceeded mean population age standards.

Conclusion: The character of lipid and lipoprotein spectrum changes suggests marked atherosclerotic changes in the young age group. Thus, the risk of early atherosclerosis is higher in persons exposed to low-dose ionizing radiation in an early age which necessitates more careful investigation of the lipid spectrum in this group during the check-ups.

Key words: Chornobyl accident, low-dose ionizing radiation, disturbances of lipid metabolism, early atherosclerosis.

2002, vol 10, № 2, page 152

N.O.Maznik, V.AVinnikov

The comparison of cohort cytogenetic biodosimetry data and registered doses in Chornobyl clean-up workers

Annotation

Objective: To compare the results of cohort cytogenetic biodosimetry with registered doses in Chornobyl clean-up workers (liquidators) protractedly exposed to low-dose radiation.

Materials and Methods: The cytogenetic investigation was carried out in 150 liquidators within 1 year after the end of their duty at Chornobyl zone. The unstable aberration yields were measured in metaphases of 50-hrs peripheral blood lymphocyte cultures. In the studied group the irradiation doses were registered in documents of 100 persons (dose range 17-1030 mGy). Individual cytogenetic data in liquidators have been pooled according to the registered doses in narrow dose intervals; the average dicentric and centric ring yields in dose groups have been converted into biological dose using the in vitro calibration curve (g -rays) modified for protracted exposure. The theoretical distribution of individual aberration yields expected from the registered doses has been constructed using the Poisson statistics.

Results: The biological dose estimations exceeded the average meanings of registered dose in all dose groups except one with highest doses (820-1030 mGy). The average aberration yield in liquidators with registered doses were converted into biological dose that appeared to be 1.8 times higher than the mean registered dose. The statistical difference between the real aberration yield distribution and the theoretical one was found to be caused by a low number of persons with high chromosome exchange levels in the distribution expected from the registered dose meanings.

The average dicentric and centric ring yield and the distribution of individual aberration levels in liquidators with non-registered doses was shown to be the same as in the group with registered doses. When the cytogenetic data from persons with or without registered dose were combined, the mean biological dose about 470 mGy was calculated from the average chromosome exchange yield, and the individual aberration levels appeared to be randomly distributed among liquidators according to Poisson statistics.

Conclusion: The poor agreement between registered doses and biodosimetry results was shown for significant partion of liquidators. That causes the necessity of radiation dose verification in these persons using methods of retrospective biological dosimetry. To optimize the cytogenetic biodosimetry in post-Chornobyl human cohorts the emphasis should be made on the critical groups.

Кey words: chromosome aberrations, biological dosimetry, Chornobyl liquidators.

2002, vol 10, № 2, page 159

E.M.Gorban, I.M.Zvyagolska

The change of peroxidation processes in the guinea-pig organism as a result of gamma-ray action and their correction with the help of peptid complex derived from erythrocytes

Annotation

Objective: To study the changes of peroxidation processes in the organism of guinea-pigs caused by the influence of single and chronic gamma-irradiation and to investigate the possibility of their correction with the help of the peptid extract, received from erythrocytes (PEE).

Material and Methods: Four serieses of experiments were carried out with 120 guinea-pigs. Four groups of animals participated in each series: a – control; b – irradiation; c – irradiation + isotonic NaCl solution injection; d – irradiation + PEE injection.

The animals of group b, c and d of the 1st and 2nd serieses were irradiated with gamma-rays during 6 days (every day dosage being 1 Gy, Cobalt unit “AGAT-2”), and of the 3d and 4th series were irradiated once at the dose of 4.5 Gy. In all 4 serieses the irradiated animals of group d were injected intramuscularly by PEE, received with the original method 0.1 mg one body mass kilogram per day. The animals of the 1st and 2nd series were injected PEE for 6 days simultaneous to irradiation; the animals of the 3d series were injected PEE for 6 days after single irradiation; the animals of the 4th series were injected PEE for 14 days after a one-time irradiation. The irradiated animals of group c of all series of experiments were injected isotonic NaCl solution according to the same protocol.

The blood level of the malonic dialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity were estimated; peroxid resistance of erythrocytes (PRE) was studied.

The blood for the investigation was taken from the animals of the 1st and 3d series on the 7th day of the research; of the 2nd series – 12 days after the beginning of the experiment; of the 4th series – 14 days after the beginning of the experiment.

Results: No differencies between investigated indices in groups b and c of irradiated animals were noticed in all serieses of experiments, therefore the indices of these series was were similar in groups b – c. In the irradiated animals of group b – c in serieses 1st and 2nd inhibition of lipid peroxydation (LPO) was observed; the 3d series animals had tendency to activation of LPO against a background of enzymes antioxidant activity reduction; in series 4th the activity of antioxidant enzymes was increased. The injection of PEE to the irradiated animals (group d) compared to group b – c in the 1st series restored of PRE and did not change essentially the other indices; in the 2nd series it increase SOD activitiy; in the 3th series no positive effect of PEE injection was noticed; in the 4th series it produced maximal corrective effect: considerable decrease of LPO intensity with simultaneous increase of SOD activity.

Conclusion: The expressiveness of the data changes of peroxidation processes in gamma-irradiated guinea-pigs is evaluated with the dosage, irradiation repeating times and the days of the observation after irradiation. PEE injection slows the correcting influence of the changes mentioned, the degree of its effectiveness depending on the factors mentioned above: dosage, irradiation repeating times, the dates of observation and duration of PEE injection.

Key words: peroxidation processes, gamma- irradiation, peptid complexes from erythrocytes, correction.

2002, vol 10, № 2, page 163

E.M.Gorban, N.V.Topolnikova

The influence of ionizing radiation on the nervous regulation of adrenal cortex and pancreas

Annotation

Objective: To study the peculiarities of nervous regulation of glucocorticoid function of adrenal glands“ (AG) cortex and insulogenic function of pancreas at exposure to single x-irradiation in sublethal dose.

Material and Methods: The experiment was conducted on adult Wistar male rats. Selective pharmacological inhibition of separate components of nervous regulation (a - or b -adrenergic, M-cholinergic) was provided by intraperitoneal injection twice a day for 3 days at a dose of 10 mg/kg body weight of corresponding reactive structure blocker (pirroxan, anaprilline or atropine). The animals were exposed to single x-irradiation at a dose of 4 Gy next day after the last injection and were tested in an hour after irradiation. We determined 11-oxycorticosteroids (11-OCS) secretion intensity by isolated AG, blood insulin and glucose levels.

Results: One hour after x-irradiation the intensity of 11-OCS secretion by isolated AG and blood insulin level were increased. Chronic injection of a - or b -adrenergic blockers did not influence intensity of 11-OCS secretion by isolated AG, blood insulin and glucose levels, but prevented intensity of 11-OCS secretion and blood insulin level changes in irradiated animals. Chronic injection of M-cholinergic blockers resulted in an essential activation of 11-OCS secretion by isolated AG and increase of blood insulin level. Subsequent x-irradiation did not influence the intensity of 11-OCS secretion by isolated AG and blood insulin level when compared with the same parameters caused by chronic atropine injection only.

Conclusion: a - or b -adrenergic components of nervous regulation of glucocorticoid function of AG and insulogenic function of pancreas does not influence essentially the intensity of 11-OCS secretion by isolated AG and blood insulin level in unirradiated rats, provide activation effect on indicated parameters upon a single x-irradiation in sublethal dose. Cholinergic component of nervous regulation provides tonic inhibitor effect on gluco­corticoid function of AG and insulogenic function of pancreas in unirradiated rats and maintains under effect of single x-irradiation in sublethal dose.

Key words: x-irradiation, adrenal glands, pancreas, nervous regulation.

2002, vol 10, № 2, page 167

P.I.Kratenko, A.B.Mitryaev

The effect of ionizing radiation and 12-crown-4 on phospholipid composition of erythrocytes and hepatocytes in white rats

Annotation

Objective: To compare the effect of 12-crown-4 and ionizing radiation on phospholipid composition of erythrocyte and hepatocyte membranes of white rats in subacute experiment.

Material and Methods: Group 1 of experimental animals were administered water emulsion of 12-crown-4 1/1000 LD50 for 15 days. Group 2 of experimental animal were exposed to chronic total irradiation generated with Experiment unit (Russia) with Co-60 source. To analyze phospholipid composition, erythrocytes separated from plasma with sodium chloride solution at 3-4 fold centrifuging were used. The amount of total and individual phospholipids in lipid extractions was evaluated according to the amount of non-organic phosphorus, which was determined with molybdenum reagent and colorimetry. The ratio of phospholipid fraction was calculated as percentage of phospholipid phosphorus of each fraction to the sum of phosphorus of all phospholipid taken as 100%.

Results: In hepatocyte, the both factors increased the amount of phosphatidyl cholines and cardiolipins (significantly only for 12-crown-4), reducing the percentage of phosphatidyl inositoles (significantly only for 12-crown-4) and sphyngomyelins. The percentage of phosphatidyl serins and phosphatidyl ethanolamines did not change. Lysoforms of phosphatidyl ethanolamines and phosphatidyl cholines in hepatocytes and erythrocytes of the rats of both experimental animals increased significantly, which could be the consequence of free-radical processes activation and lipid peroxidation.

Conclusion: The effect of ionizing radiation and 12-crown-4 influences considerably phospholipid composition of erythrocyte and hepatocyte membranes, changing the ratio of the fractions and elevating the percentage of phospholipid lysoforms. Similar character of the changes caused by ionizing radiation and 12-crown-4 suggests the presence of radiomimetic properties in the latter.

Key words: ionizing radiation, crown-ethers, phospholipids, biological membranes, hepatocytes, erythrocytes.

2002, vol 10, № 2, page 174

E.B.Radzishevska, T.MPopovska, O.M.Gladkova, O.O.Solodovnikova

The use of cluster analysis for description of immunological homeostasis system in oncology patient

Annotation

Material and Methods: The following immunological parameters were studied using monoclonal antibodies: CD4, CD8, CD20, CD 56, CD95, CD45RA and HLA DR.

The parameters of immune homeostasis were analyzed in 22 patients with breast cancer (BC), 12 patients with uterine body cancer (UBC) and 9 patients with lung cancer (LC). Cluster analysis was performed with the method of analysis of K-medians and correlation analysis.

Results: Optimum number of classes equaled 5. Among a sufficiently large amount of possible classifications we chose this one because of the originally formulated principle of “quality” of classification as the association of the parameters and the norm. Only when divided into 5 clusters, each of the parameters can be regarded as one gradation of the norm: below normal, normal, above normal.

The obtained classification was stable. Its stability was checked by changes of the sample volume. It was proven that the volume of the investigated sample did not influence the composition of the taxonomy, that is the patients taken to one cluster remain in the same cluster with the changes in the volume of the sample.

There was no difference in the division into clusters in patients with BC and LC. This conclusion was drawn with subsequent exclusion of each nosological form from the total sample and further checking the stability of distribution into clusters.

It was impossible to analyze immune parameters of UBC patients together with the other nosological forms, as the division into clusters was not obvious.

Conclusion: The use the methods of multidimensional analysis in medicine allows to reveal complicated non-obvious regularities of functioning biological systems and the human organism.

Key words: multidimensional statistical analysis, cluster analysis, oncoimmunology, monoclonal antibodies.

2002, vol 10, № 2, page 181

N.M.Belyaeva, N.A.Semenyuk, L.O.Storoguk, E.Y.Galyutina, V.P.Kochmar, V.G.Grirgoryants

Disability due to hemoblastosis in some regions of Ukraine

Annotation

Objective: To study the persons with disability caused by hemoblastosis in the regions which suffered after the accident in Chornobyl when compared with similar patients from clean regions.

Material and Methods: Medical documentation (case histories, directions to examinations in medico-social expert commissions, extracts from case histories) of 190 disabled patients examined in Zhytomyr, Vinnytsia and Khmelnitsky Regions in 1998-2000

Results: The study of the group of patients disabled due to hemoblastoses in the regions contaminated after the accident at Chornobyl Atomic Power Plant in comparison with similar patients from relatively clean territories demonstrated characteristic features of disability increase due to chronic lympholeucosis in elderly and old persons, mainly men with marked and moderate clinical manifestations of the disease and determining group 1 and 2 disability due to either a general disease or associated with the consequences of the accident in Chornobyl.

Conclusion: The reported results correspond to the literature data which suggest increase of chronic lympholeucosis incidence in old patient of the contaminated territoties. This process is manifested by the increase of the number of invalids with this pathology which was established in our study.

Key words: disability, hemoblastosis, disability group, Chornobyl accident, victims of the Chornobyl accident.

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